If you are using DistributedRST or RSTPublicTests, you will need to make sure you have set up RSTTestServers. If you are using RSTPublicTests, you will also want to make sure everything has been done for PreparingPublicTestsAtStartOfTerm.
The other main consideration is the command-line interface.
Many people who have used RST in the past may be comfortable with its interface; however, the command-line specifics are inconsistent amongst various supported commands. Another option is described at RSTVersionTwo, which streamlines the command-line and also provides other options (for example, to restrict printOut
to a subset of students).